| 1. | MCOOrlando Orlando International AirportUnited States | Nov 14, 2026 | 142 | SJU > MCO |
| 2. | MIAMiami Miami International AirportUnited States | Nov 14, 2026 | 109 | SJU > MIA |
| 3. | STTSt. Thomas St. Thomas Cyril E. King AirportU.S. Virgin Islands | Nov 13, 2026 | 98 | SJU > STT |
| 4. | EISBeef Island Beef Island Terrance B. Lettsome AirportBritish Virgin Islands | Nov 13, 2026 | 65 | SJU > EIS |
| 5. | BWIBaltimore Baltimore Washington International AirportUnited States | Nov 14, 2026 | 51 | SJU > BWI |
| 6. | FLLFort Lauderdale Fort Lauderdale Hollywood International AirportUnited States | Nov 14, 2026 | 46 | SJU > FLL |
| 7. | SBHSt. Jean St. Jean Gustaf III AirportSaint Barthelemy | Nov 14, 2026 | 45 | SJU > SBH |
| 8. | VQSVieques Vieques Antonio Rivera Rodriguez AirportPuerto Rico | Nov 14, 2026 | 38 | SJU > VQS |
| 9. | TPATampa Tampa International AirportUnited States | Nov 13, 2026 | 37 | SJU > TPA |
| 10. | JFKNew York New York John F. Kennedy International AirportUnited States | Nov 14, 2026 | 36 | SJU > JFK |
| 11. | SDQSanto Domingo Santo Domingo Las Americas International AirportDominican Republic | Nov 13, 2026 | 28 | SJU > SDQ |
| 12. | BOSBoston Boston Logan International AirportUnited States | Nov 14, 2026 | 27 | SJU > BOS |
| 13. | PHLPhiladelphia Philadelphia International AirportUnited States | Nov 14, 2026 | 26 | SJU > PHL |
| 14. | EWRNew York New York Newark Liberty International AirportUnited States | Nov 14, 2026 | 24 | SJU > EWR |
| 15. | ATLAtlanta Atlanta Hartsfield-Jackson International AirportUnited States | Nov 14, 2026 | 22 | SJU > ATL |
| 16. | STXSt. Croix St. Croix Henry E. Rohlsen AirportU.S. Virgin Islands | Nov 13, 2026 | 22 | SJU > STX |
| 17. | ORDChicago Chicago O'Hare International AirportUnited States | Nov 13, 2026 | 22 | SJU > ORD |
| 18. | PUJPunta Cana Punta Cana International AirportDominican Republic | Nov 14, 2026 | 18 | SJU > PUJ |
| 19. | VIJVirgin Gorda Virgin Gorda AirportBritish Virgin Islands | Nov 13, 2026 | 18 | SJU > VIJ |
| 20. | CLTCharlotte Charlotte Douglas International AirportUnited States | Nov 14, 2026 | 17 | SJU > CLT |
| 21. | DFWDallas Dallas Fort Worth International AirportUnited States | Nov 14, 2026 | 16 | SJU > DFW |
| 22. | BOGBogota Bogota El Dorado International AirportColombia | Nov 13, 2026 | 12 | SJU > BOG |
| 23. | MAZMayaguez Mayaguez Eugenio Maria de HostosPuerto Rico | Nov 13, 2026 | 12 | SJU > MAZ |
| 24. | SXMSint Maarten Sint Maarten Princess Juliana International AirportSint Maarten | Nov 13, 2026 | 11 | SJU > SXM |
| 25. | CPXIsla De Culebra Isla De Culebra Benjamin Rivera Noriega AirportPuerto Rico | Nov 14, 2026 | 10 | SJU > CPX |
| 26. | DOMDominica Dominica Melville Hall AirportDominica | Nov 13, 2026 | 10 | SJU > DOM |
| 27. | BNANashville Nashville International AirportUnited States | Nov 7, 2026 | 10 | SJU > BNA |
| 28. | MDWChicago Chicago Midway International AirportUnited States | Nov 7, 2026 | 10 | SJU > MDW |
| 29. | HOUHouston Houston William P. Hobby AirportUnited States | Nov 7, 2026 | 9 | SJU > HOU |
| 30. | CVGCincinnati Cincinnati Northern Kentucky International AirportUnited States | Nov 14, 2026 | 8 | SJU > CVG |
| 31. | YYZToronto Toronto Pearson International AirportCanada | Nov 13, 2026 | 8 | SJU > YYZ |
| 32. | AXAThe Valley The Valley Clayton J. Lloyd International AirportAnguilla | Nov 12, 2026 | 8 | SJU > AXA |
| 33. | MDEMedellin Medellin International AirportColombia | Nov 14, 2026 | 7 | SJU > MDE |
| 34. | MSPMinneapolis Minneapolis Saint Paul International AirportUnited States | Nov 7, 2026 | 7 | SJU > MSP |
| 35. | AUSAustin Austin Bergstrom International AirportUnited States | Nov 7, 2026 | 7 | SJU > AUS |
| 36. | STLSt. Louis St. Louis Lambert International AirportUnited States | Nov 7, 2026 | 7 | SJU > STL |
| 37. | PTYPanama City Panama City Tocumen International AirportPanama | Nov 14, 2026 | 6 | SJU > PTY |
| 38. | STISantiago de los Caballeros Santiago de los Caballeros Cibao International AirportDominican Republic | Nov 13, 2026 | 6 | SJU > STI |
| 39. | SAPSan Pedro Sula San Pedro Sula La Mesa International AirportHonduras | Nov 9, 2026 | 6 | SJU > SAP |
| 40. | MADMadrid Madrid Barajas AirportSpain | Nov 14, 2026 | 5 | SJU > MAD |
| 41. | RDURaleigh-Durham Raleigh-Durham International AirportUnited States | Nov 13, 2026 | 5 | SJU > RDU |
| 42. | IAHHouston Houston George Bush Intercontinental AirportUnited States | Nov 13, 2026 | 5 | SJU > IAH |
| 43. | BDLWindsor Locks Windsor Locks Bradley International AirportUnited States | Nov 13, 2026 | 5 | SJU > BDL |
| 44. | SKBBasseterre Basseterre Robert L. Bradshaw International AirportSaint Kitts And Nevis | Nov 12, 2026 | 5 | SJU > SKB |
| 45. | MGAManagua Managua Augusto C. Sandino International AirportNicaragua | Nov 12, 2026 | 5 | SJU > MGA |
| 46. | LALLakeland Lakeland Linder International AirportUnited States | Nov 13, 2026 | 4 | SJU > LAL |
| 47. | ILGWilmington Wilmington New Castle AirportUnited States | Nov 14, 2026 | 3 | SJU > ILG |
| 48. | IADWashington Washington Dulles International AirportUnited States | Nov 13, 2026 | 3 | SJU > IAD |
| 49. | HVNNew Haven New Haven Tweed AirportUnited States | Nov 13, 2026 | 3 | SJU > HVN |
| 50. | UIOQuito Quito Mariscal Sucre International AirportEcuador | Nov 14, 2026 | 2 | SJU > UIO |